New Stanford tool enables wider analyses of genome 'deep sequencing'

From PhysOrg.com:

The new Stanford-developed, web-based algorithm allows scientists to plumb the unprecedented depths of the data provided by new "deep-sequencing" techniques to reveal a pantheon of control regions for nearly any gene. The effect is like expanding a researcher's field of vision from a pencil-thin beam of light trained mainly on the regions near coding sequences to a sweeping spotlight illuminating the contributions of distant genomic regions.

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Scientists discover new genetic sub-code

From PhysOrg.com:

In a multidisciplinary approach, Professor Yves Barral, from the Biology Department at ETH Zurich and the computer scientists Dr. Gina Cannarozzi and Professor Gaston Gonnet, from the Computer Science Department of ETH Zurich and the SIB Swiss Institute of Bioinformatics, joined forces to chase possible sub-codes in genomic information. The study, which will be published in today's issue of the journal Cell, led to the identification of novel sequence biases and their role in the control of genomic expression.

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1 gene lost = 1 limb regained? Scientists demonstrate mammalian regeneration through single gene deletion

From PhysOrg.com:

A quest that began over a decade ago with a chance observation has reached a milestone: the identification of a gene that may regulate regeneration in mammals. The absence of this single gene, called p21, confers a healing potential in mice long thought to have been lost through evolution and reserved for creatures like flatworms, sponges, and some species of salamander. In a report published today in the Proceedings of the National Academy of Sciences, researchers from The Wistar Institute demonstrate that mice that lack the p21 gene gain the ability to regenerate lost or damaged tissue.

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Biochemists take a bead on gene-controlling code

From PhysOrg.com:

University of Wisconsin-Madison researchers have developed a new technique for observing the proteins that operate by that controlling code — called the epigenome — and assembled a library of interactions between the proteins and key positions on packets of DNA.

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What drives our genes? Researchers map the first complete human epigenome

From PhysOrg.com:

Although the human genome sequence faithfully lists (almost) every single DNA base of the roughly 3 billion bases that make up a human genome, it doesn't tell biologists much about how its function is regulated. Now, researchers at the Salk Institute provide the first detailed map of the human epigenome, the layer of genetic control beyond the regulation inherent in the sequence of the genes themselves.

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Model unravels rules that govern how genes are switched on and off

Model unravels rules that govern how genes are switched on and off from PhysOrg.com

For years, scientists have struggled to decipher the genetic instruction book that details where and when the 20,000 genes in a human cell will be turned on or off. Different genes operate in each cell type at different times, and this careful orchestration is what ultimately distinguishes a brain cell from a liver or skin cell.

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