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Insulin Resistance: The Problem May Be "Bone Deep"

According the the article Skeletal Discovery: Bone cells affect metabolism:

If your blood glucose is out of whack, the problem may be in your bones. New research in mice shows that bone cells exert a surprising influence on how the body regulates sugar, energy, and fat.

The discovery could lead to new ways to treat type 2 diabetes, a disease involving poor regulation of blood glucose. It also means that skeletons act as endocrine organs, which affect other body tissues by releasing hormones into the bloodstream.
"This could also have important ramifications for cardiovascular disease because of the effect on metabolic syndrome," a condition related to diabetes, comments Dana T. Graves of Boston University. "The fact that bone cells regulate energy metabolism, and that they do it through osteocalcin, is a major finding," he says.

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