Insulin Resistance: The Problem May Be "Bone Deep"

According the the article Skeletal Discovery: Bone cells affect metabolism:

If your blood glucose is out of whack, the problem may be in your bones. New research in mice shows that bone cells exert a surprising influence on how the body regulates sugar, energy, and fat.

The discovery could lead to new ways to treat type 2 diabetes, a disease involving poor regulation of blood glucose. It also means that skeletons act as endocrine organs, which affect other body tissues by releasing hormones into the bloodstream.
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"This could also have important ramifications for cardiovascular disease because of the effect on metabolic syndrome," a condition related to diabetes, comments Dana T. Graves of Boston University. "The fact that bone cells regulate energy metabolism, and that they do it through osteocalcin, is a major finding," he says.

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